Anxious to start a biologic
Some background info: I was diagnosed with UC (specifically ulcerative proctitis) about 8 years ago and have been using mesalamine (oral route) mostly successfully since then. Initially, I was taking oral and suppository mesalamine and had off and on (mild-ish) flares until around 2020. At that point I had a pretty bad flare and was on prednisone for about 6 months (during covid, couldn’t go into Dr’s office). And eventually told to taper off and see where my body was at. I had a colonoscopy in 2022 that showed I was in remission.
Fast forward to this last summer I noticed flare symptoms come on quickly and increase and was having 12+ bms a day, severe cramping, lethargy, snd weight loss (10+ lbs in a two week period). As soon as I was seen by my dr I was put on 20mg prednisone and my mesalamine dose increased from 2.4mg/ day to 4.8. A few weeks after taking prednisone was able to get a colonoscopy. The colonoscopy showed that my colitis is mainly active in my left colon.
I’ve now been on prednisone and the increased dose of mesalamine for 4 months. I’m currently feeling ok-ish. I’m definitely having some adverse side effects of the prednisone. My Dr is encouraging me to start Skyrizi and I was able to get prior authorization. She is also concerned that if I were to stop taking prednisone my symptoms would return. I guess I am just feeling very anxious about the switch and all of the “what ifs”. Maybe I’m in denial that my UC is actually getting worse and wishing I could stay on an easier-to-access med? Might also be gaslighting myself a bit into thinking it’s “not that bad”.
Am I in the wrong for wondering if there are any other things I should ask about before starting a biologic for the first time? Other meds? Dietary changes? Or are there any tips to help ease the anxiety?
Posted Dec 10, 2025, 2:57 AM UTC