Obvious duos

Looking at the 50 cast and there are so many really obvious duos or trios that have worked closely together in the past. There's Savannah & Rizo, Kyle & Kamila (+Joe sort of), Cirie & Aubrey worked together in GC.

How much of a factor do you think this will be in the season. Will they be immediate targets or will some of the duos join forces to make voting blocks to take out the lone wolves?

Really interested in hearing what people think the dynamics will be like.