r/Endo•
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Here for Hail Mary non hormonal suggestions!

Medications and pain management

Hi all. Quick info about me, I’m 36F. I have had stage 2 endo and severe/diffuse adeno. I’ve had two excision surgeries; the first was very successful until the endo grew back a few years later with severe adeno. I believe the adeno is causing the large majority of my pain, issues and symptoms. Through this I was able to have two successful pregnancies via IVF/fertility clinic. I randomly have mild non alcoholic fatty liver and no one knows why, sludge in my gallbladder, and positive ANA with a high-average titer. I have plans to have a colonoscopy in April to ensure I don’t have an IBD especially since I have a lot of gastro based symptoms as well.

I’m out of hormonal options at this point. The last attempt was Norethindrone which probably seemed the most promising at first after the initial emotional/mood swing adjustment but after a month in, the acid reflux kept increasing, my hair was falling out, I was starting to get cystic acne and most troublesome was beginning to have daily severe migraines and I was told to stop it. I’m currently coming off of it which has been as rough as getting adjusted to it, woof.

My endo specialist and I are at the last stop of a hysterectomy for the adeno symptoms, leaving my ovaries intact. The surgery would remove my uterus and my cervix (I’ve had DIE throughout my cervix causing me funky pap results and a lot of cervical pain so I can’t wait for it to go away). My fallopians were riddled with endo and were already removed during my previous excision surgery.

Although I’m done with kids, I still am hesitant to immediately jump to hysterectomy at 36 years old. Just want to see if there are any non hormonal options to consider. Here are some of my ideas but wanting to hear from others and I’ll take any opinions you have:

-paying OOP for a low dose glp-1 for the anti inflammatory properties -same thing but doing either contrave (I have depression anyway) or just LDN -anything else??

I already eat an anti-inflammatory diet. I try to workout when I can handle it pain wise and do Pilates and cardio, and have done pelvic floor PT for years. I take vitamins and supplements. Am I missing anything? Or should I just go ahead with hysterectomy once my colonoscopy is done and (assumed) normal?

Thanks everyone!

Posted Dec 30, 2025, 8:56 PM UTC

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