How does the curse of devil fruits apply in other oceans?

Hypothetically Luffy went for a in the pacific ocean on earth, would he still suffer the curse of eating a devil fruit or is it that it only applies to the sea of which the Sea God "resided". They where affected on skypia and by seastone, but again that is all connected to the same sea, so how does it work on another planet, if the moon had water can Enel swim in it just fine or would he drown>