Has anyone’s mood changed for months after stopping Zoloft/sertraline?
I had taken it for three years and felt very stable. I shouldn’t have listened to the devil on my shoulder suggesting I try to taper off.
I followed advice of a doctor and decreased the dose over weeks. I thought I was okay but the following months after I was extremely irritable. Snapping at my boyfriend. Crying all the time. Horrible PMS symptoms I was so angry it felt like I wasn’t in my own body.
I did have other life stressors but genuinely my mood was so horrible and out of the ordinary. My partner of 5 years left me even when I told him I was going to start meds again. It has been such a hard period for me.
Has anyone else experienced this. I’m not sure if my brain has a chemical imbalance so stopping the sertraline went back to the unbalanced state. Or if it’s because my body was so used to it for 3 years that I was having withdrawal symptoms even months later?
Posted Jan 25, 2026, 4:39 AM UTC