Rising heart rate and severe withdrawel symptoms after just a few doses of mirtazapine?
My GP prescribed mirtazapine 15mg for insomnia that I'd been dealing with for a month.
My dosing timeline:
- Started January 6th
- Jan 6-7: 7.5mg
- Jan 8: 3.75mg (split tablet)
- Jan 9-13: Stopped (severe rebound insomnia, extreme exhaustion)
- Jan 14: Took 15mg once due to inability to function
- Jan 15-22: Off medication
- Jan 23: Took 15mg (heart rate hit 100 from sleep deprivation, felt desperate)
Current symptoms:
- Resting heart rate jumped from average 69 bpm to consistently 94-100 bpm (even when relaxed)
- Shortness of breath
- Dry mouth/cotton mouth
- Cold chills
- What feels like blood pressure fluctuations
Last night while calmly watching TV, my watch alerted me that my HR was 99.
I called the after-hours GP service and they said these are side effects and to wait until tomorrow to see my regular GP. I've only taken 4 tablets total over 18 days, but I'm experiencing what feels like severe withdrawal symptoms when I stop. The rebound insomnia is brutal and I'm caught in a cycle where I get so sleep-deprived that I feel forced to take it again.
I'm seeing my GP tomorrow to discuss discontinuing this medication properly, but I'm genuinely concerned about these physical symptoms - especially the elevated heart rate and breathing issues.
Has anyone else experienced these symptoms on mirtazapine? Is this normal or should I be more worried? Any advice on managing discontinuation after short-term use?
Posted Jan 25, 2026, 12:30 PM UTC