Traveling during spring break?

We are considering traveling to Europe from the US for my son’s spring break. My son is in kindergarten and he has two younger sisters (3 yo and 12 mo). Has anyone done something similar? Does this seem like a bad idea due to jet lag? We haven’t traveled internationally with our kids yet but would like to try and take the plunge but I’m worried about how my kids will adjust when we get back and they have school and are still jet lagged.