Igor Branchi‘s idea of antidepressant way of effect coined „susceptibility to change model“ proposed already in 2011 seems to be breathtakingly plausible
What you should take note of in detail from first to last paragraph is the following publication:
Igor Branchi, The double edged sword of neural plasticity: Increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover. Psychoneuroendocrinology, Volume 36, Issue 3, 2011, Pages 339-351, ISSN 0306-4530, https://doi.org/10.1016/j.psyneuen.2010.08.011
Gratefully available for free from the author himself via researchgate: https://www.researchgate.net/publication/46577889_The_double_edged_sword_of_neural_plasticity_Increasing_serotonin_levels_leads_to_both_greater_vulnerability_to_depression_and_improved_capacity_to_recover
Why seems this not to be common sense yet?
What do you think about it?
(And wouldn’t be tianeptin a kind of burnout prophylaxis in highly dangerous environments?)
Posted Feb 7, 2026, 11:04 PM UTC