If we were almost certain we live in a simulation, what would that actually change for ethics or the meaning of life?

A lot of discussions about the simulation hypothesis focus on whether it’s true or not, or how likely it is. But I’m more curious about the practical and philosophical consequences.

Suppose we became almost certain (not 100%, but close) that we live in a simulation. Would that really change anything important about how we should live, what we value, or how we think about meaning and responsibility?

For example, would it affect moral responsibility, the value of experiences, or long-term goals? Or would it mostly be like other skeptical scenarios, interesting intellectually but with very little impact on everyday ethics and meaning?

I’m interested in serious philosophical perspectives on this, not just sci-fi takes.