Anyone else have shockingly good response to methyl-B12 but cyano-B12 did practically nothing?
I'm having the most insane week, luteal phase was as unbearable as it's always been my entire life but after taking methyl-B12 I feel almost normal. It was a dissolvable tablet under the tongue, started feeling more energy within 10 minutes and mood also improved and held steady. Not feeling amazing or anything but the debilitating storm cloud disappeared. I'm on an anti anxiety and anti depressant too but they made almost no difference to my PMDD symptoms.
But I've also already been taking the more common cyano B12 in high doses daily for months, and I know from a blood test I'm not low in B12. I truly expected this other form of B12 to make no difference whatsoever, I thought it would be basically the same as the other kind.
Is this some kind of insane placebo effect? Has anyone else had this happen?
Posted Feb 16, 2026, 8:27 PM UTC