Taking 15mg for anxiety- would like to stop

36 F, I’ve been on 15mg mirtazapine for almost two years now, previously I’d been on pristiq for years and Zoloft before that. Pristiq was awful to wean off of and I dread doing that again.

Mirtazapine has helped me a lot. I have generalized and social anxiety to the point of severe stomach upset, to the point that before I was medicated I was underweight, nauseous all the time and barely able to eat. SSRIs helped the anxiety but I’d still get stomach upset / panic attack symptoms for out of the ordinary circumstances (big events I was dreading, stressful occurrences etc), and complete loss of libido that was really really damaging to my relationship.

Mirtazapine has helped with the stomach issues so so much. It’s amazing. And I have my libido back. However I’ve had the normal 15 lbs of weight gain, which I absolutely hate. I feel like I just look puffy and even though I am very active the weight isnt budging. I did learn that if I took it right before I went to sleep that helped a lot with the cravings, but I’m not losing the weight. I also have higher lipid levels on blood draws than I used to, and slightly high cholesterol.

I’m worried about trying something else or tapering off, as I’ve been medicated the entirety of my adult life, and all the women in my family on both sides have bad anxiety, but I also don’t like the weight gain and blood level changes. I’d like to know if anyone else has the same type of anxiety manifestation with stomach issues and what you’ve done to help, and what else has helped besides mirtazapine. Thanks everyone

Posted Feb 16, 2026, 8:33 PM UTC

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