If VO2 max can be “gamed” by losing weight, what does it mean when you are at FFMI 21-22?

FFMI 21-22 for a male is a solid 15-20 lbs of lean tissue weight above a similar male that only runs. Does that mean the FFMI 21-22 person’s VO2 max is penalized to an extent? Not sure how to understand the weight component and relation to lean tissue, when I thought the formula fully accounts for it, but people are reporting massive vo2 max gains after losing weight.