Itinerary Advice- 6.5 weeks in Peru. Add Bolivia or Ecuador?

Hello! My wife and I are landing in Lima April 8th and will have 6.5 weeks to travel in Peru and nearby regions.

We have yet to book our return flight. We are avid hikers and we could easily occupy ourselves in Peru doing multi-day treks out of Cusco and Huaraz. We plan to visit Arequipa and Puerto Maldonado also, each for about 5 days.

Currently we are torn about spending this entire time only in Peru, though. We are considering going north from Huaraz and into Ecuador to fly home from Quito, but we are concerned about the current safety situation and crossing a land border. We are also considering skipping Huaraz and heading south from the Amazon down to Bolivia, likely ending our trip in Santiago.

We like to travel pretty slow, but we will be taking some domestic flights. Cost is a consideration for us also, so adding a lot more bus and plane fare to see Bolivia/Chile when we could see the Peruvian high country more thoroughly is a tough call to make.

Anybody travel these regions and have some advice? Would we kick ourselves for missing out on Bolivia? Of all the countries in consideration, it would definitely be the hardest one to return to. How about the safety situation in Ecuador/at the border in Mancora?

Thanks in advance.