Slow responders

I’m wondering why some people are such quick responders to even and especially- low doses like .25. I’m headed into week 6 now (my 2nd dose of .5) and am frustrated to see negligible weight changes despite lowering my carbs and calorie consumption and having a regular work out and walking routine. I know I’m not on a “therapeutic dose” just yet but I wonder- are slow responders losing weight more slowly because they are more insulin resistant??