Stiff, sore hands that wake me up at night

I was diagnosed with CVID December 2023 and started SCIG with Cuvitru May 2024. I have noticed in the past 6 months or so that I frequently wake up at night with stiff, sore hands. The middle knuckles are particularly sore. This now has evolved to mild to moderate hand pain and stiffness during the day. I know this could just be normal OA that is developing, but I seem to always get “rare” or “unusual” diseases or infections so I immediately started wondering whether this could be CVID-related. I have not noticed any swelling, redness, or fevers. Has anybody else developed these symptoms that have turned out to be CVID-related? Thanks

Posted Feb 20, 2026, 4:25 PM UTC

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