Drinking on Reta (help)

So I’ve been on Reta for 12 weeks now. Down 30lbs so far. Starting dose was 1mg the first week to assess tolerance, bumped it up to 2mg and stayed on that for 5 weeks, and now running 3mg/week.

My main question I have is how are people dealing with the flat dopamine response while having a night out drinking on Reta? Are there any supplements or other peptides people take to combat this?

My lifestyle has changed for the better after starting Reta. Healthy eating, hitting my protein goals, working out consistently all week. But I also still like to go out every couple months to wind up with friends/family. The issue is “I cannot enjoy myself no matter how much I drink”. I’m an introvert so before I started Reta I was known to need a couple drinks to get that buzz to feel more comfortable in a larger social setting. Now it doesn’t matter how much I drink I don’t feel any effect from alcohol. I can feel my body slowing down but my brain feels like it functions as if I’m sober.

I’m curious if anyone else has experienced the same side effects and how you’ve dealt with them. Or is this just maybe a sign I should cut out alcohol entirely?

Posted Feb 21, 2026, 5:34 PM UTC

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