Anyone else have more stomach issues on Zep than Wegovy?
Zepbound on the average is supposed to have fewer gastric side effects than Wegovy from what I've heard. I'm finding the opposite.
I was on Wegovy for about 2 years with no side effects. I tried to see if I could taper off of it, started gaining weight, realized that this is a lifetime drug for me, and switched to Zepbound since it's a bit more effective. I've been on Zep now for a little over a year (started at 10mg, got up to 15mg, and now at 12.5, going back to 10 next week). Every week I get a stomach ache starting about 8 hours after my injection and lasting about a day. I'm in the process of lowering the dosage to see if I can find a sweet spot where I'm still maintaining but not getting the side effect. But I'm strongly considering just going back to Wegovy.
Anyone else?
Posted Feb 23, 2026, 7:31 PM UTC