Retatrutide and Sermorelin — first ever experience with ukw
wanted to post a complete, objective log since firsthand retatrutide reports are still limited, especially from people who already lost weight naturally first.
Male, 5’11”
Starting weight (December 2025): 210 lbs
Current weight: 190 lbs
Current Retatrutide start weight: 195.6 lbs
Before touching any GLP compounds, I made a major lifestyle change starting in December:
• Strict 2100 calorie daily intake
• 170 g protein per day minimum
• Consistent training and adherence
Lost 15 lbs naturally before introducing retatrutide
Retatrutide protocol
Reconstitution:
10 mg vial + 2 mL bacteriostatic water
Concentration = 5 mg/mL
10 units = 0.5 mg
Injection dates:
02/17/2026 — 10 units (0.5 mg)
02/23/2026 — 10 units (0.5 mg)
Total so far: 1.0 mg
Subjective effects so far:
Nothing noticeable yet.
• No appetite suppression
• No nausea
• No fatigue
• No side effects
• Hunger levels unchanged
What stands out is my girlfriend started lsemaglutide literally yesterday and noticed appetite suppression the same day. Retatrutide has not produced anything noticeable yet at this dose.
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Sermorelin protocol (secondary)
Reconstitution:
5 mg vial + 2 mL bacteriostatic water
8 units = 0.2 mg
Injection dates:
02/20
02/21
02/22
02/24
Observation:
I feel like I’ve definitely noticed falling into a way deeper sleep with this compound, which is what really drove me to take it, plus the lean muscle mass gain, because I have sleeping problems
On 02/22, I wayyy overslept my alarm, keep in mind, though the night before I only got two hours of sleep due to an unrelated reason. But I slept for 14 hours
No other clear effects.
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Important context
My appetite was already controlled from months of strict dieting before starting retatrutide.
I was not overeating prior to starting. Hunger was manageable already.
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Current status at 1.0 mg total Retatrutide
No noticeable:
• appetite suppression
• physiological effects
• side effects
• energy changes
Continuing protocol and tracking objectively.
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Question for those with real experience:
At what total dose did you first notice clear appetite suppression or physiological effects from retatrutide?
And finally, any thoughts on my stack?
Posted Feb 25, 2026, 5:31 AM UTC