Retatrutide and Sermorelin — first ever experience with ukw

wanted to post a complete, objective log since firsthand retatrutide reports are still limited, especially from people who already lost weight naturally first.

Male, 5’11”

Starting weight (December 2025): 210 lbs

Current weight: 190 lbs

Current Retatrutide start weight: 195.6 lbs

Before touching any GLP compounds, I made a major lifestyle change starting in December:

•	Strict 2100 calorie daily intake

•	170 g protein per day minimum

•	Consistent training and adherence

Lost 15 lbs naturally before introducing retatrutide

Retatrutide protocol

Reconstitution:

10 mg vial + 2 mL bacteriostatic water

Concentration = 5 mg/mL

10 units = 0.5 mg

Injection dates:

02/17/2026 — 10 units (0.5 mg)

02/23/2026 — 10 units (0.5 mg)

Total so far: 1.0 mg

Subjective effects so far:

Nothing noticeable yet.

•	No appetite suppression

•	No nausea

•	No fatigue

•	No side effects

•	Hunger levels unchanged

What stands out is my girlfriend started lsemaglutide literally yesterday and noticed appetite suppression the same day. Retatrutide has not produced anything noticeable yet at this dose.

⸻

Sermorelin protocol (secondary)

Reconstitution:

5 mg vial + 2 mL bacteriostatic water

8 units = 0.2 mg

Injection dates:

02/20

02/21

02/22

02/24

Observation:

I feel like I’ve definitely noticed falling into a way deeper sleep with this compound, which is what really drove me to take it, plus the lean muscle mass gain, because I have sleeping problems

On 02/22, I wayyy overslept my alarm, keep in mind, though the night before I only got two hours of sleep due to an unrelated reason. But I slept for 14 hours

No other clear effects.

⸻

Important context

My appetite was already controlled from months of strict dieting before starting retatrutide.

I was not overeating prior to starting. Hunger was manageable already.

⸻

Current status at 1.0 mg total Retatrutide

No noticeable:

•	appetite suppression

•	physiological effects

•	side effects

•	energy changes

Continuing protocol and tracking objectively.

⸻

Question for those with real experience:

At what total dose did you first notice clear appetite suppression or physiological effects from retatrutide?

And finally, any thoughts on my stack?

Posted Feb 25, 2026, 5:31 AM UTC

03
Loading comments…