Hey guys i have since 4-6 years hardly this histamin problem, i went to many doctors specially wellness clinics in thailland, itried many things and hade done 14 days only riece only diet, have tried 3 days dry fasting (only recommend if you expierences, and yes i am) but my itching was not gone.

But i felt much better, now i start noticing that even with DAO enzymes and even without eating food i sometimes get itchings and was wondering, what i am doing wrong and got really depressed, i really wanted to give up and say, okay, that's how it is now and i start eating everything again, and I don't give a want to give a s*hit about anything.

Then i have done some more research and found out:
My histamine issues weren’t about DAO production deficiency in the gut — they were caused by a lack of methyl groups. A cheap ancestry DNA kit (nothing fancy, around 30$) gave me the raw data I uploaded to geneticgenie.org and interpreted with Gemini. Showed me that I don’t break down dopamine and adrenaline efficiently, so my body’s “methyl-vitamin” pool was empty and histamine piled up.

Since I started taking TMG and CDL-Cholin, an inexpensive, high-dose methyl-group donor — my methylation resumed, my “histamine barrel” could finally drain, and symptoms like itching disappeared even without a strict histamine-free diet. So yes i am still avoiding histamin food, but and taking encymes for food digestion because i still have sibo and my DAO production in the gut is not healed, but i dont have any random itching anymore and feel much better.

Now i am focusing on killing SIBO which i got from food poisoning in egypt and healing my DAO "baby" productions in the gut, because some antibiotics destroyed it.

But my itching is completly gone and my "DAO" and other enzyms are finally working..

My Supplements at the moment are:

1. Methylation Hub (Drain for Histamine & Stress)

• TMG Betaine – Main methyl-donor: clears the histamine backlog and lowers homocysteine to protect heart and brain.
• CDP-Choline – Supplies choline (can convert to TMG) and builds acetylcholine for sharper focus—clean brain fuel.
• Vitamin B2 (Riboflavin) – The ignition key for the MTHFR switch; without it the whole metabolic engine stalls.
• Natural Folate (B9) – The bio-active folic-acid form that keeps the cycle running so cells can repair.
• Hydroxycobalamin (B12) – Safest B-12 for a sluggish COMT enzyme: boosts energy without the jitters or aggression that methyl-B12 can cause.

2. Cooling (Brain’s Brake Pedal)

• Magnesium L-Threonate – “Brain magnesium” that crosses the blood–brain barrier, chills an overactive COMT and stops mental overdrive.
• L-Theanine – Puts the brain in alpha mode (alert yet calm); takes the edge off adrenaline.

3. VDR-Taq Reset (Immune Command & Testosterone)

• Vitamin D3 + K2 (MK-7) – Your survival hormone; K2 steers calcium into bones instead of arteries.
• Boron (3 mg) – Door-opener for a stubborn VDR-Taq variant: makes cells more responsive to vitamin D and lifts free testosterone.
• Zinc Bisglycinate – The DNA-repair tool; without zinc, vitamin-D signalling can’t give orders to cells.

4. CBS Shield & Detox (Itch-Stop & Liver Support)

• Taurine – Protective shield for a sensitive CBS pathway: calms itching, nerves, and aids bile flow.
• Molybdenum – Converts toxic sulfites (from meat/garlic) into harmless sulfates—vital for this sulfur pathway quirk.
• Yucca Extract – Binds ammonia in the gut (from high-protein meals) and prevents post-meal brain fog.
• Zeolite – A mineral sponge that soaks up histamine, heavy metals, and bacterial toxins in the gut before they hit the bloodstream.

5. Gut Elite & Inflammation Stop

• Vegan DAO – A direct “fire extinguisher” in the gut: neutralizes food histamine (think Adana kebab!) before it floods your system.
• Apo-Lactoferrin – SIBO-buster: starves bad bacteria by stealing iron and strengthens the gut lining.
• Vegan Omega-3 (Algal Oil) – Pure anti-inflammation; keeps cells flexible and prevents COMT from getting blocked by inflammatory stress.

One last important thing:

^(These things worked for me, but that doesn't mean they'll work for you in exact same way. Everyone's body is different and unique. This is just meant to be just "my experience".)
^(But still maybe you'll see some similarities in some things.)

^(My advice would be, before you take anything (if you can afford it, its just 30-50$), take the cheap ancestry DNA test and then you can do a lot more with the raw files and analyze them on free sites. That opened my eyes in all areas. And i know that know Gemini or any other analyze platform has it, but i was struggeling with my health for so long and i can't afford any other king of a expensive DNA test at the moment. So yeah, that was my reasons.)

^(Just keep in mind, you don't need 5-10k for a dna testing doctor.)
^(If you have any questions or tell me your symtoms, feel free to ask..)

^(I really know how hard the struggle is.)
^(Stay healthy and try enjoying the good things. Peace.)