Is the USB used to reboot an infected pc by reinstalling windows, safe to use after the installation?

Downloaded the Windows Media Creation Tool to my USB, with another 'healthy' device... Say I use it to reboot an infected pc, is there a possibility of that infection spreading to the usb mid installation? Or is everything wiped from the usb too after the reinstallation? Cuz I'd like to use that USB to move my files from the 'healthy' pc to the rebooted pc too...and I'd like it to stay healthy.