Is this a good buy in parts?

https://pcpartpicker.com/list/66HD3R

New here, so not sure if this works with the link. Mainly in doubt about the different company's in GPU, as there is a lot of price difference. Can you give your thoughts on where I should focus on/what's the important differences?

I'm a single player RPG kind of gamer. Never game online. Looking for a PC that can run all the new SP RPG's like Witcher 4 or BG3 anything like that.