Can't lose weight?

Hi there! I have a friend who has being struggling with their weight for 7-8 years. It's mystery weight-gain. I have my suspects of what is happening, but what do you all think?

Symptoms

• "Hormone imbalance", since childhood but not discovered until recently
• "Little thing in her brain that tells her she's full", doesn't work. Her biological mother has this too, so suspected she inherited from her mother
• Cannot lose weight no matter what she does, nor how much she tries

Context

• Prescriptions: monjaro(appetite suppressant and laxative)
• Fitness: active(1 hour long walks everyday-to-second-day)
• Monjaro neither makes her gain or lose weight
• Doctors don't know why she is the weight she is now
• Cooks homemade meals; eats clean and healthy
• Body is always in "hunger mode"; when food goes in it apparently "instantly puts it into fat preservatives"

Questions

• Is this mystery weight due to EBV and/or shingles?
• Is this mystery weight due to a fat, sluggish, overburdened liver?
• Would the a369 cleanse be a proper solution for this problem?