Anxiety Meds and HRT
Long time lurker, first time poster.
I've been on Zoloft for about 5 years and 75 mg has worked well for me. I started having peri symptoms 2 years ago quite young (38) and have finally gotten on HRT about 4 months ago. I'm currently on the .05 estradiol patch and progesterone.
The dose was working well at first, but like I've seen many other people experience, I've had a lot of rebound symptoms in the last month. Hot flashes, night sweats worse, trouble sleeping, etc.
One of my central symptoms is how bad my anxiety gets the week or so before my period. This was getting better on HRT at first but then got worse the last two months.
I'm speaking with my midi doctor on Monday to discuss trying a higher dosage. however, I'm also wondering if I should try upping my dosage of Zoloft.
Has anyone had experience tackling their peri symptoms with combining both antidepressants and hormones? Zoloft has worked well for me, but obviously the root of the exacerbated anxiety is my hormonal imbalance. I'd love to hear what's worked well for others!
Posted Feb 28, 2026, 1:15 PM UTC