Multiple Spider-Man villains have personal ties to Spider-Man especially when you factor in adaptations

Green Goblin - Best friend or best friend's father/mentor

Doc Ock - Almost Uncle-In Law, Science Camp Instructor, Science Idol, Boss

Venom - Childhood friend, Bugle Co-worker 

Lizard - College professor, Intern supervisor, research partner with Peter's father

Sandman - Uncle Ben's killer, thug often busted by Spider-Man before getting powers

Rhino - Thug often busted by Spider-Man before getting powers

Vulture - Father of Peter's Homecoming date

Kraven - Mentored Spider-Man in hunting criminals 

Kingpin - Owner of Spider-Man merchandising rights

Hydro-Man - Mary Jane's ex-boyfriend 

Molten Man - Liz Allen's brother and Mary Jane's boyfriend 

Electro - Spider-Man fan

Jackal - College professor 

Screwball - Midtown High classmate

Rocket Racer - Student 

Boomerang - Roomate

Morbius - Rival classmate

Black Cat - Tutor recepient, on/off girlfriend to Peter, daughter of Uncle Ben's killer 

Man Wolf - Son of Peter's boss

What are your thoughts about villains having personal ties to Peter/Spider-Man?

What are your favorite instances of this trope when it comes to Spider-Man?

If you were to come up with ways that a villain would have personal ties to Spider-Man, what would they be?

Tinkerer - Peter's employer and boss when Peter was working at a repair shop or Peter's workshop teacher

Mysterio - Show business person that was outdone by Spider-Man before he was a crime fighter

Roderick Kingsley - Mary Jane's boss

Electro - Uncle Ben's co-worker as an electrician

Jackal - Gwen's Uncle and Peter's science teacher 

Prowler - Uncle to Miles who Peter is mentoring

Spider-Man's Personal Ties To Villains