Meds have never worked for me

I’ve been on anti-depression/anti-anxiety medication for the past 10 years since I was 13. I have tried different meds, different combinations of meds, and I have never felt a difference. Sometimes I’m late to getting refills and will go a few days without them and it’s just the same. I don’t think medication works for me or something. People’s main suggestions for dealing with depression are meds and therapy, and I’ve been in therapy for most of my life. It’s not a depression fixer, it keeps me sane and closer to functioning as a normal person. I haven’t really been able to find anyone else who has this problem. Can anyone relate? What can I do about this?