Can guilt, shame, and or self hatred block your connection to your spiritual side?

To be brief I made a horrible mistake I am currently unable to even want to forgive myself for.

I’m dealing with ^ in therapy but since it happened I’ve felt almost as if my soul had been torn out of my body, or the connection to it was blocked or removed outright.

I don’t really feel alive anymore, I feel almost like a walking corpse it’s really strange and disconcerting.

I seem to have lost the ability to connect with any spiritual phenomena as well.

Thanks.