One year into unemployment, the lows do, in fact, get lower

I'm looking for help? Or solidarity? Not sure anymore. I'm 1 yr post layoff with no current prospects. I have 8 yrs of experience, no PhD, and I feel like I'm doing something wrong. I've had 4 final interviews, all rejected. When it comes to big pharma interviews, have I just burned down any possibility of being hired for another position in the near future?

My HR interviews I always nail and I have a pretty great success rate with hiring manager interviews but when it comes to in person I can't seem to stick the landing. I've tried several different seminars now but I'm at a loss. I have no papers that I'm on that I can discuss in a seminar and I'm very limited on discussing any of the interesting elements of research I've done in biotech because of the obvious restrictions.

I've considered trying a new career, but honestly nothing interests me besides research.

Tips for nailing my in-person interviews and seminar? Tips for staying sane? Feeling lost.