Another tie but I chose Mephisto for Dante

1. Superman vs Frieza
2. SpongeBob vs Anton Ego
3. Mario vs Asgore
4. Goku vs Dimentio
5. Sonic vs Megatron
6. Mickey Mouse vs The Black Hat Organization
7. Optimus Prime vs Vilgax
8. The Doctor vs Makima
9. Kratos vs Gorr The God Butcher
10. Captain America vs Homelander
11. Batman vs Nemesis (from Icon Comics)
12. Cloud Strife vs Griffith
13. Master Chief vs Tyranids
14. Iron Man vs Senator Armstrong
15. Spider-Man vs Alex Mercer
16. Bugs Bunny vs Freddy Krueger
17. Ash and Pikachu vs Zongazonga
18. Godzilla vs Cthulhu
19. Indiana Jones vs Lyle Tiberius Rourke
20. Kirby vs Galactus
21. Luigi vs Beetlejuice
22. Link vs Sauron
23. TMNT vs Kingpin
24. Monkey D. Luffy vs King K. Rool
25. Naruto Uzumaki vs Mahito
26. Mega Man vs Ultron
27. Shrek vs The Princess (from Slay the Princess)
28. Luke Skywalker vs Necrons (from Warhammer 40K)
29. Ben Tennyson vs High Evolutionary
30. Saitama vs Mr Mxyzptlk
31. Midoriya vs Syndrome
32. Harry Potter vs Father (from Fullmetal Alchemist)
33. Roman Reigns vs Shao Kahn
34. Ryu vs Sukuna
35. Po vs Akuma
36. Samus vs Lobo
37. Donkey Kong vs King Pig
38. Gru vs Captain Cold
39. Homer Simpson vs Chester V
40. Dante vs Mephisto


Bonus: The Avengers vs IDW Shockwave

Also please tell me on how the villain would fit and I need more comments and give me some GIFs

Rule change: I need multiple villain suggestions please so that I can get more comments

And don't select characters that I don't know/never heard of

Heroes vs Villain roster: Today, we're doing Pac-Man