In our latest modded space age session we created this slightly cursed kovarex setup.

As you can see there is not a traditional loop. Inserters left to right:

1. Picks up uranium (235 and 238) off the belt. Uses the constant (r) plus the content of the centrifuge (g) to set the filter using integer overflow. This loads/keeps 40 u235 and 5 u238.
2. Picks up and drops off on the same tile. This moves the items from the centrifuge output back into the input very fast.
3. When there is enough spicy rocks in the loop we pull some out 4 at a time.

You will need [Bob's Adjustable Inserters](https://mods.factorio.com/mod/bobinserters) for this to work since it looks like vanilla resets inserters on loading the blueprint.

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This is why we can't have nice things: Kovarex Edition