Renting a car in Rome - what do I need to know ?

Hey all,

I am in Rome at the moment and I want to go out of the city (either to Tuscany or Napoli, haven’t decided yet)

But I am very confused from the driving rules about rules I understand what ZTL is, but I am confused and I don’t fully understand what are the restrictions for the city, is it only through the historic centers ?

In Google Maps the whole city circumferences is highlighted in RED AND WHITE strip

Any tips will be welcomed