Does flavored vodka matter?

Hello! I recently turned 21, and all I really drink are simple vodka cocktails or vodka lemonades, screwdrivers, that sort of thing.

I was wondering, does it really make much of a difference if you use flavored or plain vodka? I hate the taste of alcohol so I use enough mixer to mostly cover it anyway. For example, would it make a difference if I used a citrus flavored vodka in a vodka lemonade instead of plain? Or watermelon flavored with watermelon juice?

How noticeable is it if I don't make them very strong?

Thanks in advance!