Act 3 Enemy RNG

Does anyone ever feel like the game specifically gives you bosses and super overturned hallway enemies that specifically counter your deck in act 3 that throw your entire run?

Context: had an amazing AOE/single target doom deck going with decent block and got the trio of armored enemies which was fine took 20 damage but then got soul nexus right after that scales from 20 to 50 damage every turn in 2 turns?? This happened three runs in a row too.