Pituitary Cancer risk mitragynine and Estradiol interaction

I currently am taking .1mg estradiol through transdermal patches changing 2 times a week. I have also been taking ~8g of powdered Kratom daily. I looked into their drug interaction and am concerned about them both raising my prolactin levels. My main concern is potential risk of developing pituitary tumors. How concerned should I be haha

I am 22 amab 5”9’ and use zyn