What should we do with DEPLORABLES?

Say theoretically that 15% of America consists of genetic deplorables. They are genetically predisposed to act in a way that the other 85% find truly abhorrent. (They tend to be selfish, steal, grape, murder, etc.) These 15% consists of our brothers, our mothers, and our friends.

What is the ideal solution to deal with these deplorables?

For example, should society cast them out? Neuter them?

What would be the optimal solution?