r/Zepbound•
onemorefirst

No weight loss and strange appetite first week - Anyone else?

First Timer

Started Zepbound a week ago and did my second dose just now. This first week, I didn't lose any weight, and my appetite has been weird and hard to manage. I took Wegovy previously -- more about that below.

For three or four days after the first Zepbound shot, I didn't have much interest in eating until I got super hungry. I would go without eating until dinnertime. Once I ate, I would feel very hungry until bedtime.

I could tell eating anything else would make me feel sick because dinner was in my stomach, but the hunger signal was there. A couple of those days, I would wake up very hungry the next morning and eat something small and then feel uninterested in eating until dinnertime again and very hungry after dinner.

The last few days of the week, I felt very hungry all day and never felt satisfied after eating.

This is different from my experience on Wegovy, both in my initial weight loss (almost 10lbs in week one on Wegovy) and how it's affecting me.

I had some success on Wegovy a couple of years ago (50 lbs lost in about 4 months) but stopped it due to severe constipation. (Taking Miralax daily now since starting Zepbound, and no issues so far.) On Wegovy, I would want to stop eating after having just a small portion, but I didn't go long periods without eating or wanting to eat.

Is this a common experience starting out? Not upset about it. I know everyone is different and things can take awhile, but it's annoying and I was wondering if there's anyone who had a similar experience and how that progressed for you.

Thank you!

Posted Mar 30, 2026, 6:04 AM UTC

66
Loading comments…