Supplements effects?

Dear all,

In the research articles discussing PSSD treatment*, as well as in the Examine.com article 'Libido & Sexual Function Supplement Guide', the authors propose several supplements as potential treatment options for sexual dysfunction.

In this group, I have seen some positive, neutral and negative experiences related to these supplements.

What if we try collecting more opinions in a more systematic way, starting with the comments under this post?

Supplements:

- Panax ginseng

- Maca

- Arginine / Cirtrulline

- Yohimbine

- Tongkat ali

- Fenugreek

- Tribulus terrestris

- Ginko Biloba

- Saffron

- EDOVIS

- Probiotics

- Horny goat weed

- Damiana

I can start by saying that:

1

My symptoms after 4 months of Sertraline 50 mg 2,5 years ago are low libido and inconsistent erections. (I have also taken St John’s Wort and Ashwagandha KSM66 for 2 months each, but did not notice any negative effect of those on my sexual function).

2

Arginine and Cirtrulline 3 g daily: clearly improved my erections, almost to the level of Cialis, but more long-term and without headache.

3

Cordyceps: no effect.

4

Saffron: no effect.

5

Shilajit: maybe a slight improvement of desire.

—

*

- Calabrò, Rocco Salvatore, Rosaria De Luca, Alfredo Manuli, Simona Portaro, Antonino Naro, and Fabrizio Quattrini. 2019. ‘Towards Improving Post-SSRI Sexual Dysfunction by Using Nutriceuticals: Lessons from a Case Study’. Journal of Sex & Marital Therapy 45(6):562–65. doi:10.1080/0092623X.2018.1556755.

- Reisman, Yacov, Tommaso B. Jannini, and Emmanuele A. Jannini. 2022. ‘Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions(PSSD): Clinical Experience with a Multimodal Approach’. Journal of Men’s Health 18(8):1. doi:10.31083/j.jomh1808165.

- Woźniak, Weronika Maria, Katarzyna Wiktoria Witczak, Zuzanna Winiarska, Marcin Wieleba, and Ewelina Anna Soroka. 2025. ‘Antidepressants and Sexual Health – How to Improve Patients’ Quality of Life?’ Current Problems of Psychiatry 26:108–17. doi:10.12923/2353-8627/2025-0010.

- Cormio, Luigi, Mario De Siati, Fabrizio Lorusso, Oscar Selvaggio, Lucia Mirabella, Francesca Sanguedolce, and Giuseppe Carrieri. 2011. ‘Oral L-Citrulline Supplementation Improves Erection Hardness in Men With Mild Erectile Dysfunction’. Urology 77(1):119–22. doi:10.1016/j.urology.2010.08.028.

- Jing, Elizabeth, and Kristyn Straw-Wilson. 2016. ‘Sexual Dysfunction in Selective Serotonin Reuptake Inhibitors (SSRIs) and Potential Solutions: A Narrative Literature Review’. The Mental Health Clinician 6(4):191–96. doi:10.9740/mhc.2016.07.191.

- Zubair, Muhammad. 2016. ‘Effects of Asphaltum (Shilajit) on Male Reproductive System (Mini Review)’. Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery 6(3):1. doi:10.5455/spatula.20160413015359.

- Luca, Rosaria De, Mirjam Bonanno, Alfredo Manuli, and Rocco Salvatore Calabrò. 2022. ‘Cutting the First Turf to Heal Post-SSRI Sexual Dysfunction: A Male Retrospective Cohort Study’. Medicines 9(9). doi:10.3390/medicines9090045.