Those with a heavy/unstable head or weak neck - collagen supplements are key!
For some months, I would face weird discomfort/pain in my neck. I knew this was the onset of CCI (craniocervical instability), because I'd be dizzy/uncomfortable if I was on a bumpy road etc. This worsened in February, when I did some off-roading in an SUV. Post that day, my head started feeling super "heavy" and "unstable", as if my neck is not able to hold it in one place. Even walking started feeling uncomfortable. Classic symptoms of CCI. GPT told me this could be due to inflammed neck muscles, or due to connective tissues going weaker.
Fast forward to today, much of that February heaviness has gone. I am now able to look down at my phone for extended periods without feeling pain/discomfort. I shall also start physical therapy soon.
What worked - I started digging for reasons why this happens. Apparently, both MCAS and mitochondrial dysfunction lead to breakdown of collagen due to inflammation (MMP signals). This results in weaker ligaments/tendons and connective tissues, and your neck is not able to do its job properly. Research led me to Collagen Type I and Type III for connective tissues (Type II works well for joints, meanwhile, since it creates cartilage). I started supplementing 20g every single day.
Finally, I also kickstarted production of collagen in my body by taking GHK-Cu peptide (along with KPV for the inflammation) - 2mg every day. It started working in just 2 weeks - how do I know? The injection would pierce my skin easily 3 weeks back, now it's not able to do that - I have to use literal force to inject into my sub-q fat. This means the skin is more elastic, therefore more collagen.
TLDR - if you feel you have a weak/strained/painful neck, try Collagen supplementation (20g+) every day for at least 4 weeks. And try GHK-Cu peptide (or KLOW in its mixed form) for at least 1 month to restart collagen production. ME/CFS / MCAS causes connective tissue to break down, and it can't be easily regenerated, unlike other parts in your body. It's of utmost importance that you don't allow that to happen then. Thank God I didn't listen to the neck doctor I went to and opted for a surgery right away...
I'm sure I'm not the first one to figure this out, but I have tried and tested out this theory, and clearly it's working. Hoping to get the word out! Thanks.
Posted Apr 3, 2026, 4:47 PM UTC