Three years of observing the community

January 2023: several confident posts explaining why an effective oral GLP-1 was pharmacologically impossible due to peptide degradation in the gut.

January 2026: oral Wegovy approved. Orforglipron approval imminent. Aleniglipron heading into Phase 3 with 16% placebo-adjusted weight loss.

I'm not mocking anyone. Confident impossibility claims about drug development have a terrible track record and this community makes them regularly about pipeline drugs.