Spravato for MH with Chronic Illness- Bumpy Ride
Wondering if anyone else on their spravato journey also struggles with chronic illness like me? I have Lyme Disease which is chronic due to late diagnosis and have been in spravato treatment for my MH for the last 6 weeks. The spravato is intended to help with my mental health diagnoses which include treatment-resistant major depressive disorder, PTSD, ADHD, insomnia..(I think that pretty much covers itπ€) but I guess, I was also secretly hoping maybe it might help with pain associated with my Lyme just a bit, as well. My first couple treatments I was enthusiastic, because I didn't have pain during or following treatment..I didn't even have nausea, which was normal for me to experience, like regularly throughout the week. After a couple weeks in I have been experiencing what might be considered "rebounding" pain or perhaps a herximer reaction of sorts as my body tries to metabolize the drug, or heal?? Idk. Also, mood swings that include agitated mood and anxiety has been more prounced at times, which have nothing to do with the Lyme, or my mental health symptomology prior to this treatment. I just wanted to report on that mood/ emotional instability piece as well, as part of my not so purely positive experience. But I guess I am posting because it's been hard to gauge my progress as increased pain flares, mood swings, and surmounting life stressors such as managing my weekly workload in three working day's (during the twice a week phase)/ financial issues, etc. has made progress unclear. If you have chronic illness you might know how increased frequency and severity of pain affects mood and with the addition of additional symptoms/ stressors, it's hard to gauge any markers of meaningful mood improvement.π π΅βπ«π
I'm posting for 3 reasons:
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Mental Health Outcomes- Looking for hope/ encouragement/ commonalities/ suggestions of what markers of progress that might be there that I'm missing. Can all this still mean progress/ good outcomes?
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Chronic Illness As a Layer/ Compounding Variable- To know I'm not alone- has anyone had to manage chronic illness symptoms while undergoing this treatment? Did it help in unintended ways with pain long term? Is it worth the pain flares with no notable/ significant MH progress observed this far in?
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Inform/ Connect- To share my experience, because nothing prepared me for worsening health symptoms related to my chronic illness until I really dug for that information and found little there. If you are having a less then easy time with spravato, whether it be unanticipated mood instability or physical health flares, you are not alone!!!β€οΈβπ©Ή
Posted Apr 5, 2026, 2:51 AM UTC