Help (cat inappropriately urinating)

I am desperate and need help before I lose my mind. My cat, almost 6 years old, has started urinating inappropriately for the past several months. He never used to do this, ever, until I moved apartments almost a year ago. He had moved several times before and never had an issue until now. It started in my closet, peeing on clothes left on the floor and never happened in any other space. Gradually, he got worse. He moved to only urinating in my closet to urinating on things left on the floor in my bedroom. Fast forward to now, it’s absolutely out of control (but still limited to my bedroom for now so it seems very targeted towards me out of anger or spite). He has urinated on shoes, in my leather work tote bag, my bed, comforter, sheets, books, heating pad, clothes left on top of my desk, chair, you name it. I’ve taken him to the vet MULTIPLE times, bloodwork, urine sample, everything came back fine. I have a calming diffuser (doesn’t work), he’s now on amitriptyline (anti anxiety med), changed his food, litter box, natures miracle enzyme cleaner, literally everything. It just seems to be getting worse. I’m at my wits end and fear I will give him away if this keeps happening. I have no idea what to do now bc I feel like I’ve tried everything. Should I lock him in my bathroom with the litter box to “retrain him”? (He has no problem pooping in the litter box- that has never been an issue). I’m at a loss. Please help.