r/bipolar•
Wild_Lily43

Question for the Women

Living With Bipolar

Question for my fellow females diagnosed w/ bipolar disorder -

Background: I have bipolar 1 disorder. I'm on a combo of antipsychotics and mood stabilizer that has me the most stable I've ever been. I've been on this combo for about 4 years with some minor tweaks as needed. Back before I was stable I would suffer from coma-like depressions and extreme manic episodes & hallucinations.

The problem now is that I've noticed when I'm about to get my period /get my period it's almost like my meds arent as effective or the hormones from my period over ride the medicine. I don't get hallucinations, but I start to get rage episodes. The worst part of it is that I get extremely tired like my coma-like depression tireds where I can't get out of bed to save my life. I know it's bipolar depression related because I feel the same way I do when I go into one of my bipolar depressions.

Does anyone else relate to this? Does medicine stop being as effective when you get your period? Is there a way to mitigate it? How do you cope/handle this when it comes up if this also comes up for you? What has been effective? It's so beyond frustrating because it's making it really hard to stay employed and keep up with school work when I get into that week-long slump.

Posted Apr 5, 2026, 10:05 AM UTC

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