Question for the Women

Discussion

Question for my fellow females diagnosed w/ bipolar disorder -

Background: I'm 29. I have bipolar 1 disorder. I take rexulti and Lamictal. This combo has me the most stable I've ever been. I've been on this combo for about 4 years with some tweaks here and there. Back before I was stable I would suffer from coma-like depressions and extreme manic episodes & hallucinations.

The problem now is that I've noticed when I'm about to get my period /get my period it's almost like the medicine isnt as effective. I don't get hallucinations, but I start to get rage episodes again. The worst part of it is that I get extremely tired like my coma-like depression tireds where I can't get out of bed to save my life. I know it's bipolar depression related because I feel the same way I do when I go into one of my bipolar depressions.

Does anyone else relate to this? In your experience does medicine stop being as effective when you get your period? Is there a way to mitigate it? What do you do during your period to cope with the hormones interacting with your illness? It's so beyond frustrating because it's making it really hard to stay employed and keep up with school work when I get into that week-long slump.

Posted Apr 5, 2026, 10:16 AM UTC

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