Intermediate COMT

Just wanted to catch this sub’s opinion and knowledge regarding calcium d-glucarate. So I have intermediate COMT based on my Ancestry genetic results and wondering if this will help? I’ve been on mono therapy for nearly two years now and during my entire time on hrt I’ve had to take relatively high levels to reach wpath level ranges. When it comes to injections I inject twice a week 6mg EV (12mg a week total). This was what was needed to just reach the mentioned ranges for over a year. But my recent blood tests have been showing no less than 600 pg/ml (all at a trough of 3.5/4 days depending on appointment timing) My feminization has been ok I suppose on hrt. But would my intermediate COMT be a potential why my levels have risen without a change in dose or schedule? Would calcium d-glucarate be of any benefit to help flush out any metabolites building up?