[QCrit] Is it a bad idea to comp two titles from different genres if your book is an intentional combination of those genres?

First of all, sorry if this is the wrong tag.

I'm working on a query for a book that is a deliberate combination of two genres. does it seem ok in this case to comp two different genres? will that be confusing? I'm wondering if it's better to just comp one genre if I can get away with that, even if it's not super representative of the book.