How to handle taxes

Why does no one talk about taxes (USA). Quarterly taxes at 43% (fed+state).

What is the trade algorithm to follow knowing that for every time you sell you have to pay 43% tax on the gains and likely hit wash sales on the losses.

When do you decide to go for a ride hoping that the market doesn't wipe 43% of profits before turns around.

I opted to go for a long term gains, but got more than wiped out in February-March.

I don't day trade so I cannot set up as Mark to Market.

Hoping someone has some good pointers on how to navigate.