Best bedding ? What is better, synthetic or natural cotton

Let's be honest we spent third of our lives dreaming and our bedding is a total lifestyle essential. I found these 440 thread count cotton white sheets at Royal Luxury Linen. They are made from 100% cotton, nice and soft and more importantly they get softer after repeated washes and they are ethically Made In USA. I am getting a nice restful sleep, since its cotton it is a natural temperature regulator keeping you cool comfy and cozy. I tried various synthetic fabrics but if I compare all natural cotton is the best and these days it's getting hard to get good quality sheets at a reasonable price. Please comment with your thoughts and if there any other choices.