Possible meanings of “arrugarsele”? (Context below)

I heard the phrase “Se le arruga a ella” within a conversation with a slangy, joking tone, so I assume that it doesn’t mean “to wrinkle.” It might be Mexican slang, as a Mexican said it, but the only other (slang) meaning of “arrugar” I could find online was “to frighten”, which I don’t think is it. Again, for reference, the speaker who said this phrase was previously saying things like “la neta me la pelas” and “andas valiendo verga” (all as a joke). I can only think that maybe it means something similar to “me la pela”? As in the speaker was saying “she doesn’t give a shit”? Really not sure though, your thoughts would be appreciated!