First night on LDN - anyone had this happen...?

NSFW

I've been dealing with chronic inflammation, neck pain, hypermobility just to name a very small select few and was recommended to try this medication.

I took it around 9pm (I go to bed around 12) at first I felt a bit off like wired and fuzzy simultaneously but I feel off already so it really doesn't change much. My dreams were very vivid, it wasn't a bad thing either, I was having very interesting dreams and could recall them as well really strongly.

What WAS weird though was in the middle of the night I woke up briefly to my body spontaneously reaching climax... I'm a woman for context, I've only had this happen in my life a couple times before when I've been so incredibly panicked so much so that my body seems to do it to try to calm me down or try to release the panic but it was actually quite uncomfortable/shocking. Is this a similar level of response or CNS activation or anything to worry about? Has this happened to anyone else? Sorry if I'm over sharing, I guess I'm just very confused and can't find much info on it 😵‍💫

Posted May 6, 2026, 11:25 PM UTC

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