What should I expect from starting estradiol?

Intact female age 30. I’m taking 1mg estradiol everyday and 100mg of progesterone everyday. I started about 4-5 days ago but at the same time I ran out of my spironolactone for about 2 weeks and my face is angry. I have about 4 cysts coming on and pimples everywhere. I think the acne is from the lack of spironolactone as the other hormones have only been taken for a few days and I assume not nearly long enough to reach a therapeutic level. What things did you notice in the beginning?