I am struggling here. Looking down at numbers and just. Struggling. My Frenchie Winston started having seizures two days shy of his first birthday (Jan 2025). Went through a myriad of meds but he’s NEVER made it a full 30 days without an episode. He is now two years old. Since Jan 2025 - he’s had a total of 101 seizures (many of them clustering episodes). Sixty eight of those 101 were in 2025. So 33 episodes so far for 2026. He does have very violent grand mals. And here lately he’s been having breakthrough seizures despite being on Clorazepate post seizures and being given 3mL Midazolam intranasally during his clusters. 

He’s currently taking the following meds daily:

Phenobarbital 75mg (37.5mg am/pm)  
Topiramate 200mg (100mg am/pm)  
Zonisamide 200mg (100mg am/pm)  
Keppra ER 1000mg (500mg am/pm)  
Famotidine 20mg (10mg am/pm)  
Denamarin (given at night)  
Milk Thistle liquid (given at night)  
Fish Oil liquid (given at night)  
Purina Pro Probiotic Fortiflora (given at night)

Clorazepate 15mg (given every 8hrs for 3 days post seizure)  
Midazolam 3mL (given intranasally OR rectally during a 3 min seizure or during a 3rd seizure in cluster event)

FOOD: Orijens Amazing Grains Six Fish plus Tundra freeze dried toppers (fed twice a day) — he is allergic to chicken

He is 30lbs, takes Sentinel monthly (NO correlation so far with it and seizures and we MUST have flea protection — collars and liquids made him break out horribly), he does get the occasional Cytopoint injection for seasonal allergies, and the occasional Cerenia injection when Keppra has done his tummy in. HIS LIVER ENZYMES are currently HIGH (I’m assuming due to the massive amount of meds his body is trying to filter). Not detrimentally so, but high enough to warrant CBCs every 3 months. At two years old. He’s about 30lbs and is not neutered due to his epilepsy AND a heart murmur. He cannot take CBD oil due to said heart murmur. 

HE HAS HAD:

MRI (negative)  
Spinal Tap - Initial thoughts of inflammation but then a firm negative from the neuro   
Previous use of Gabapentin  
Previous use of Keppra every 8 hrs 

He has never been consistent. And I cannot find a solid trigger. He seizes CURRENTLY around every 13-15 days. Last winter it was every 6-7 days. Hes such a happy, spunky boy. LOVES to play, FINALLY learning how to wiggle his butt and not his whole body. He’s goofy and playful, gets the zoomies, is the best snuggler around but MAN do I worry. His breakthroughs despite emergency meds make me worry horribly. What else can I do?? I feel like we’re tapping out all of our options and we’ve only been at this journey for 17months. Not even two years. I’m terrified he’s going to go into status. I’m terrified to leave him alone. I’m terrified of having to explain to my 6 yr old daughter of losing her best friend if something happens. Overall this is just a horrid situation. I’ve reached out to his breeder, tried to find family history - and nothing. We even met his brother and now they have playdates (his brother does NOT have epilepsy). Would you recommend a second opinion? Just keep trudging through the trenches?! I’m just at a loss. I HAVE mentioned KBr to the neuro and she said we’re waiting just because of its liver strain as well. 😭 He DOES get ataxia with Clorazepate and Midazolam. But other than that - he’s a happy boy. I just feel like I’m failing because nothing seems to be helping him. 😔 

Picture tax of my baby and bless you if you read through my whole ass vent session/book! 

How many is TOO many?